Promiscuous features cameo appearances by Keri Hilson, Bria Myles and Justin Timberlake. The video focuses on scenes with dancing and flirting because Furtado wanted to recreate the song's indicative vibe, and took the opportunity to film a club video for the first time. Furtado and Timbaland cannot decide whether they want to begin dating or instead flirt with others on the dance floor. Their single performances are intercut with several scenes of a dancing crowd, and the lighting changes between blue, green, red, and yellow colours.
At the 2006 MTV Video Music Awards, it was nominated for the Best Dance, Female and Pop Video Awards.